This effectively facilitates iron accumulation within the organelle, where it can be used for the synthesis of iron–sulfur clusters and possibly of heme. Irrespective of its target cell, ferric enterobactin is able to enter mitochondria, where it can bind to the α subunit of ATP synthase. Whether it is preferentially used by some host cell types or whether it has more general effects are unresolved questions. The bacterium can use the enterobactin–iron complex to help meet its own iron needs, but the complex is also able to interact with the host.
Host and Microbe Vie for Iron.Įscherichia coli in the intestinal lumen secretes the ferric iron–binding compound enterobactin, which subsequently scavenges iron. The most trusted, influential source of new medical knowledge and clinical best practices in the world.įigure 1. Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care.
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